San Antonio, TX, USA
210-258-9858
winkal@txbiomed.org

Publications

  1. How should we sample snail microbiomes? Carruthers L.V., Nordmeyer S.C., Anderson T.J.C., Chevalier F.D., Le Clec’h W. bioRxiv [Preprint]. 2024 Jun 11:2024.06.11.598555. doi:10.1101/2024.06.11.598555.
  2. Rapid phenotypic and genotypic change in a laboratory schistosome population. Jutzeler K.S., Platt R.N., Li X, Morales M, Diaz R, Le Clec’h W, Chevalier F.D., Anderson T.J.C. bioRxiv [Preprint]. 2024 Aug 8:2024.08.06.606850. doi: 10.1101/2024.08.06.606850.
  3. Susceptibility of BS90 Biomphalaria glabrata snails to infection by SmLE Schistosoma mansoni segregates as a dominant allele in a cluster of polymorphic genes for single-pass transmembrane proteins. Blouin M.S., Bollmann S.R., Le Clec’h W, Chevalier F.D., Anderson T.J.C., Tennessen J.A. Accepted in PloS Neglected Tropical Diseases.
  4. Contribution of parasite and host genotype to immunopathology of schistosome infections. Jutzeler K.S., Le Clec’h W, Chevalier F.D., Anderson T.J.C. Parasit Vectors. 2024 May 7;17(1):203. doi: 10.1186/s13071-024-06286-6.
  5. A single locus determines praziquantel response in Schistosoma mansoni. Chevalier F.D., Le Clec’h W, Berriman M, Anderson T.J.C. Antimicrob Agents Chemother. 2024 Mar 6;68(3):e0143223. doi: 10.1128/aac.
  6. Prospecting for Zoonotic Pathogens by Using Targeted DNA Enrichment. Enabulele E.E., Le Clec’h W, Roberts E.K., Thompson C.W., McDonough M.M., Ferguson A.W., et al. Emerg Infect Dis. 2023;29(8):1566-1579. doi.org/10.3201/eid2908.221818.
  7. No evidence for schistosome parasite fitness trade-offs in the intermediate and definitive host. Le Clec’h W, Chevalier F.D., Jutzeler K,  Anderson T.J.C. Parasites & Vectors. 2023 Apr 17;16(1):132. doi.org/10.1186/s13071-023-05730-3.
  8. Snails, microbiomes and schistosomes: a three-way interaction? Le Clec’h W, Nordmeyer S, Anderson T.J.C, Chevalier F.D. Trends in Parasitology. 2022 Feb 18;S1471-4922(22)00030-7. doi.org/10.1016/j.pt.2022.01.012.
  9. Genomic analysis of a parasite invasion: colonization of the Americas by the blood fluke, Schistosoma mansoni. Platt II R.N, Le Clec’h W, Chevalier F.D, Marina McDew-White M, LoVerde P.T, de Assis R.R, Oliveira G, Kinunghi S, Djirmay A.G, Steinauer M.L, Gouvras A, Rabone M, Allan F, Webster B.L, Webster J.P, Emery A, Rollinson D, Anderson T.J.C. Molecular Ecology. 2022 Feb 13. doi: 10.1111/mec.16395.
  10. Genetic analysis of praziquantel resistance in schistosome parasites implicates a Transient Receptor Potential channel. Le Clec’h W, Chevalier F.D,…, J.S Marchant, Anderson T.J.C. Science Translational Medicine. 2021 Dec 22;13(625):eabj9114. doi: 10.1126/scitranslmed.abj9114.
  11. Genetic architecture of transmission stage production and virulence in schistosome parasites. Le Clec’h W, Chevalier F.D, McDew-White M, Menon V, Arya G.A, Anderson T.J.C. Virulence. 2021 Dec;12(1):1508-1526. doi: 10.1080/21505594.2021.1932183.
  12. The hemolymph of Biomphalaria snail vectors of schistosomiasis supports a diverse microbiome. Chevalier F.D, Diaz  R, McDew-White M, Anderson T.J.C, Le Clec’h W. Environ Microbiol. 2020 Dec;22(12):5450-5466. doi: 10.1111/1462-2920.15303.
  13. Striking differences in virulence, transmission, and sporocyst growth dynamics between two schistosome populations. Le Clec’h W, Diaz R, Chevalier F.D, McDew-White M, Anderson T.J.C. Parasites & Vectors, Vol. 12(485), 2019. doi.org/10.1186/s13071-019-3741-z.
  14. Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment. Chevalier F.D, Le Clec’h W, McDew-White M, Menon V, Guzman M.A, Holloway S.P, Cao X, Taylor A.B, Kinung’hi S, Gouvras A.N, Webster B.L, Webster J.P, Emery A.M, Rollinson D, Djirmay A.G, Al Mashikhi K.M, Al Yafae S, Idris M.A, Moné H, Mouahid G, Hart P.J, LoVerde P.T, Anderson T.J.C. PLoS Pathogens. 2019 Oct 25;15(10):e1007881. doi: 10.1371/journal.ppat.1007881.
  15. Ancient hybridization and adaptive introgression of an invadolysin gene in schistosome parasites. Platt RN, McDew-White M, Le Clec’h W, Chevalier FD, Allan F, Emery AM, Garba A, Hamidou AA, Ame SM, Webster JP, Rollinson D, Webster BL, Anderson TJC. Molecular Biology and Evolution. 2019 Jun 27. pii: msz154. doi: 10.1093/molbev/msz154.
  16. Genetic crosses and linkage mapping in schistosome parasites. Anderson TJC, LoVerde PT, Le Clec’h W, Chevalier FD. Review – Trends in Parasitology. 2018 Nov;34(11):982-996. doi.org/10.1016/j.pt.2018.08.001.
  17. Whole genome amplification and exome sequencing of archived schistosome miracidia. Le Clec’h W, Chevalier FD, McDew-White M, Allan F, Webster BL, Gouvras AN, Kinunghi S, Tchuem Tchuenté LA, Garba A, Mohammed KA, Ame SM, Webster JP, Rollinson D, Emery AM, Anderson TJC. Parasitology. 2018 1–9. doi.org/10.1017/S0031182018000811.
  18. Phenotypic shift in Wolbachia virulence towards its native host across serial horizontal passages. Le Clec’h W, Dittmer J, Raimond M, Bouchon D, Sicard M. Proc Biol Sci. 2017 Jul 26;284(1859). pii: 20171076. doi: 10.1098/rspb.2017.1076.
  19. Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population. Chevalier FD, Le Clec’h W, Eng N, Rugel AR, Assis RR, Oliveira G, Holloway SP, Cao X, Hart PJ, LoVerde PT, Anderson TJ. Int J Parasitol. 2016 Jun;46(7):417-24. doi: 10.1016/j.ijpara.2016.03.006. Epub 2016 Apr 9.
  20. Real-time PCR for sexing Schistosoma mansoni cercariae. Le Clec’h W, Chevalier FD, Alves de Mattos AC, LoVerde PT, Anderson TJ. Mol Biochem Parasitol. 2016 Jan-Feb;205(1-2):35-8. doi: 10.1016/j.molbiopara.2016.03.010. Epub 2016 Mar 26.
  21. Characterization of hemolymph phenoloxidase activity in two Biomphalaria snail species and impact of Schistosoma mansoni infection. Le Clec’h W, Anderson TJ, Chevalier FD. Parasit Vectors. 2016 Jan 22;9:32. doi: 10.1186/s13071-016-1319-6.
  22. The Hematopoietic Organ: A Cornerstone for Wolbachia Propagation Between and Within Hosts. Braquart-Varnier C, Raimond M, Mappa G, Chevalier FD, Le Clec’h W, Sicard M. Front Microbiol. 2015 Dec 18;6:1424. doi: 10.3389/fmicb.2015.01424. eCollection 2015.
  23. Bidirectional cytoplasmic incompatibility caused by Wolbachia in the terrestrial isopod Porcellio dilatatus. Sicard M, Bouchon D, Ceyrac L, Raimond R, Thierry M, Le Clec’h W, Marcadé I, Caubet Y, Grève P. J Invertebr Pathol. 2014 Sep;121:28-36. doi: 10.1016/j.jip.2014.06.007. Epub 2014 Jun 28.
  24. Strength of the pathogenicity caused by feminizing Wolbachia after transfer in a new host: strain or dose effect? Le Clec’h W, Raimond M, Bouchon D, Sicard M. J Invertebr Pathol. 2014 Feb;116:18-26. doi: 10.1016/j.jip.2013.12.003. Epub 2013 Dec 15.
  25. Multi-infections of feminizing Wolbachia strains in natural populations of the terrestrial isopod Armadillidium vulgare. Valette V, Bitome Essono PY, Le Clec’h W, Johnson M, Bech N, Grandjean F. PLoS One. 2013 Dec 6;8(12):e82633. doi: 10.1371/journal.pone.0082633. eCollection 2013.
  26. Horizontal transfers of feminizing versus non-feminizing Wolbachia strains: from harmless passengers to pathogens. Le Clec’h W, Raimond M, Guillot S, Bouchon D, Sicard M. Environ Microbiol. 2013 Nov;15(11):2922-36. doi: 10.1111/1462-2920.12172. Epub 2013 Jun 27.
  27. Cannibalism and predation as paths for horizontal passage of Wolbachia between terrestrial isopods. Le Clec’h W, Chevalier FD, Genty L, Bertaux J, Bouchon D, Sicard M. PLoS One. 2013 Apr 10;8(4):e60232. doi: 10.1371/journal.pone.0060232. Print 2013.
  28. High virulence of Wolbachia after host switching: when autophagy hurts. Le Clec’h W, Braquart-Varnier C, Raimond M, Ferdy JB, Bouchon D, Sicard M. PLoS Pathog. 2012;8(8):e1002844. doi: 10.1371/journal.ppat.1002844. Epub 2012 Aug 2.

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